Table 2A.

Treatment-related adverse events ≥ 10% frequency for grade levels and all events for grade 3 or 4

Adverse events	Arm A (n = 30)		Arm B (n = 16)
	Any Grade	Grade 3–4	Any Grade	Grade 3–4
Infections
Upper respiratory infection	3 (10.0)	0 (0.0)	0 (0.0)	0 (0.0)
Shingles	0 (0.0)	0 (0.0)	2 (12.5)	0 (0.0)
Nervous system disorders
Dizziness	3 (10.0)	0 (0.0)	0 (0.0)	0 (0.0)
Neuropathy	0 (0.0)	0 (0.0)	2 (12.5)	0 (0.0)
General
Fatigue	7 (23.3)	1 (3.3)	4 (25.0)	0 (0.0)
Metabolic disorders
Hyperglycemia	4 (13.3)	1 (3.3)	2 (12.5)	0 (0.0)
Hypokalemia	4 (13.3)	0 (0.0)	0 (0.0)	0 (0.0)
Hypomagnesemia	4 (13.3)	0 (0.0)	0 (0.0)	0 (0.0)
Hypophosphatemia	3 (10.0)	0 (0.0)	0 (0.0)	0 (0.0)
Gastrointestinal disorders
Constipation	4 (13.3)	0 (0.0)	3 (18.8)	0 (0.0)
Diarrhea	10 (33.3)	1 (3.3)	0 (0.0)	0 (0.0)
Nausea	5 (16.7)	0 (0.0)	0 (0.0)	0 (0.0)
Hematologic toxicities
Anemia	6 (20.0)	2 (6.7)	4 (25.0)	1 (6.3)
Neutropenia	13 (43.3)	9 (30.0)	3 (18.8)	1 (6.3)
Thrombocytopenia	10 (33.3)	5 (16.7)	6 (37.5)	3 (18.8)
Others
CPK increased	0 (0.0)	0 (0.0)	2 (12.5)	0 (0.0)
Lipase increased	0 (0.0)	0 (0.0)	2 (12.5)	2 (12.5)