Table 2.

Comparison of patients with and without MACE

	Total (n = 289)	MACE (+) (n = 49)	MACE (–) (n = 240)	P
Age (y)	66 (59–73)	67 (59–71)	66 (59–74)	0.819
Male sex	169 (58%)	32 (65%)	137 (57%)	0.365
Obesity	14 (5%)	1 (1%)	13 (5%)	0.524
Smoking	62 (21%)	20 (41%)	42 (18%)	0.001*
Hypertension	188 (65%)	36 (74%)	152 (63%)	0.233
Diabetes	102 (35%)	29 (59%)	73 (30%)	< 0.001*
Dyslipidaemia	131 (45%)	23 (47%)	108 (45%)	0.928
Chronic kidney disease	39 (13%)	12 (25%)	27 (11%)	0.025*
CTac
AI-CACac	56 (7–461)	166 (15–716)	56 (7–461)	0.039*
log(AI-CACac + 1)	4.2 (2.2–6.2)	5.1 (2.8–6.6)	4.0 (2.1–6.1)	0.039*
> 0	271 (94%)	48 (98%)	223 (93%)	0.314
> 10	207 (72%)	41 (84%)	166 (69%)	0.060
> 28**	165 (57%)	35 (71%)	130 (54%)	0.039*
> 100	136 (47%)	28 (57%)	108 (45%)	0.163
> 400	81 (28%)	17 (35%)	64 (27%)	0.334
> 1000	35 (12%)	10 (20%)	25 (10%)	0.087
Age-adjusted risk  > 75 percentile†	84 (29%)	19 (39%)	65 (27%)	0.142
[13N]ammonia PET
Stress MBF (mL/min/g)	2.2 (1.8–2.6)	2.0 (1.6–2.3)	2.2 (1.9–2.7)	0.005*
Rest MBF (mL/min/g)	0.9 (0.7–1.0)	0.9 (0.7–1.1)	0.9 (0.7–1.0)	0.682
MFR	2.4 (2.0–3.0)	2.1 (1.8–2.7)	2.5 (2.0–3.0)	0.006*
MFR < 2.2**	93 (32%)	25 (52%)	68 (30%)	0.006*
Minimal to severe CFC reduction	133 (46%)	31 (63%)	102 (43%)	0.012*
Mild to severe CFC reduction (= impaired CFC)	70 (24%)	20 (41%)	50 (21%)	0.005*
Moderate to severe CFC reduction	11 (4%)	1 (2%)	10 (4%)	0.765
Significant ischaemia (SDS ≥ 7)	48 (17%)	13 (27%)	35 (15%)	0.087
SSS ≥ 5**	106 (37%)	27 (56%)	79 (35%)	0.010*
Stress EF (%)	58 ± 9	57 ± 10	59 ± 9	0.156
Rest EF (%)	57 ± 7	57 ± 7	57 ± 6	0.860

Data are presented as means ± standard deviations, medians (interquartile ranges) or n (%)

^*p < 0.05

^**Optimal cutoff obtained by surv_cutpoint function from the survminer package, R statistics

^†Hoff et al. Am J Cardiol 2001;87:1335–39