Table 3.

Associations of genetic risk scores in the Dutch population-based child cohort Generation R Study and ocular biometric traits

Trait	Beta (95% CI)	P	FDR adjusted P
MiRNAs (Ntested = 8)
AL 6–9 yrs	−0.0005 (−0.004–0.003)	0.76	0.83
AL 9–13 yrs	−0.0003 (−0.003–0.002)	0.83	0.83
AL/CR 13 yrs	−0.003 (−0.007–0.001)	0.17	0.56
RE 13 yrs	0.0436 (−0.036–0.123)	0.28	0.56
MiRNA BSs (Ntested = 78)
AL 6–9 yrs	−0.0004 (−0.004–0.003)	0.82	0.82
AL 9–13 yrs	−0.002 (−0.005–0.001)	0.16	0.52
AL/CR 13 yrs	−0.002 (−0.006–0.002)	0.28	0.52
RE 13 yrs	0.036 (−0.046–0.117)	0.39	0.52
Enhancers (Ntested = 43)
AL 6–9 yrs	−0.002 (−0.006–0.001)	0.13	0.13
AL 9–13 yrs	−0.003 (−0.006–−0.001)	0.01	0.02*
AL/CR 13 yrs	−0.005 (−0.009–−0.001)	8.08E−03	0.02*
RE 13 yrs	0.085 (0.008–0.162)	0.03	0.04*
LincRNAs (Ntested = 245)
AL 6–9 yrs	−0.0040 (−0.007–−0.001)	1.80E−02	0.024*
AL 9–13 yrs	−0.0048 (−0.008–−0.002)	5.92E−04	0.14E−03*
AL/CR 13 yrs	−0.007 (−0.011–−0.003)	7.47E−04	0.14E−03*
RE 13 yrs	0.081 (−0.001–0.164)	0.053	0.053

Ntested number of genetic variants tested per regulatory element, 95% CI 95% confidence interval, AL 6–9 yrs axial length elongation between 6 and 9 years of age, AL 9–13 yrs axial length elongation between 9 and 13 years of age, AL/CR 13 yrs axial length/corneal radius at 13 years of age, RE 13 yrs refractive error at 13 years of age, P P-value, FDR adjusted P false discovery rate adjusted P-value