Table 1.

Dose and schedule effects on blood stage parasite reduction.

Fos	Clin	Dose mg/kg	Schedule (qhr)	Dose #	Days of drug	Total mg/kg	Days to nadir	Parasite (x1000)/ μL nadir	Days to one million par/μL	Parasite log10 reduction ratio at 24 h	Parasite log10 reduction ratio at 48 h	Parasite log10 reduction ratio at 72 h
x		100	24	3	3	300	2.5	141	4	0.3	0.3	0.9
x		50	12	6	3	300	3	39	5	0.2	0.6	1.4
x		25	6	12	3	300	3.5	6	6	0.0	1.1	1.8
x		25	6	8	2	200	3	167	4	0.5	1.6	1.8
x		100	6	8	2	800	3	10	5	0.4	1.6	2.5
	x	25	6	8	2	200	6	37	9	0.5	0.1	0.0
x	x	25	6	8	2	200	3	87	10	0.4	1.8	2.6
	x	100	12	4	2	400	7	2	10	0.2	0.5	1.0
x	x	100	12	4	2	400	6	0.07	10	0.4	1.6	2.8
	x	100	6	8	2	800	9	0.03	13	0.3	0.6	1.4
x	x	100	6	8	2	800	9	0.02	13	0.3	1.5	2.5