. 2025 Jan 22;15:2818. doi: 10.1038/s41598-025-87314-y

Table 2.

The top 20 genes were screened through 10 topological algorithms of “cytoHubba”.

MCC	MNC	Degree	EPC	BottleNeck	EcCentricity	Closeness	Radiality	Betweenness	Stress
*ALB*	ITGAV	ITGAV	COL5A2	APOB	SPARC	ELN	ELN	IRF1	EXT1
*CD44*	*TGFB2*	TGFB2	COL5A1	TLN1	ELN	ITGA5	ITGA5	TLN1	TLN1
*COL1A1*	*FN1*	*FN1*	*FN1*	*ALB*	CD274	*FN1*	*FN1*	*FN1*	*CD44*
COL4A1	AGT	SERPINE1	TGFB2	GNG12	*ALB*	AGT	AGT	FGF10	FGF10
COL5A1	*ITGB1*	*ITGB1*	*ITGB1*	*TGFB1*	MMP2	MMP2	MMP2	*TGFB1*	TLR4
COL5A2	ITGA5	ITGA5	TIMP2	SQSTM1	*ITGB1*	SPARC	EDN1	SPARC	SPARC
COL6A1	COL6A1	COL6A1	ITGAV	KRT19	*FN1*	COL6A1	TGFB2	SQSTM1	GNG12
ELN	MMP2	MMP2	*ALB*	AGT	AGT	CAV1	CAV1	CAV1	AGT
FBN1	*COL1A1*	*COL1A1*	MMP2	*ITGB1*	EDN1	*ITGB1*	*ITGB1*	AGT	CAV1
*FN1*	*CD44*	*CD44*	*TGFB1*	TLR4	HBEGF	*CD44*	*CD44*	*ALB*	*FN1*
ITGA5	FBN1	COL4A2	AGT	G6PD	NRP1	EDN1	COL6A1	MATN2	SQSTM1
ITGAV	COL4A2	SPARC	COL4A2	TSPO	LRP1	APOB	APOB	SERPINE1	ITGA5
*ITGB1*	COL5A2	COL5A2	ELN	SPARC	*CD44*	FGF10	SPARC	G6PD	MMP2
MMP2	TGFB1	*TGFB1*	*COL1A1*	*CD44*	IL15	*TGFB1*	*ALB*	*CD44*	*ALB*
SERPINE1	CAV1	CAV1	SERPINE1	CAV1	APOB	*COL1A1*	SERPINE1	*ITGB1*	*ITGB1*
SPARC	TLR4	TLR4	COL6A1	SLC16A3	*TGFB1*	TLR4	TLR4	APOB	APOB
TAGLN	COL4A1	COL4A1	CAV1	*COL1A1*	SERPINE1	COL4A1	FGF10	GNG12	SERPINE1
*TGFB1*	*ALB*	*ALB*	*CD44*	*FN1*	TLR4	*ALB*	*TGFB1*	TLR4	*TGFB1*
TGFB2	SERPINE1	AGT	COL4A1	FGF10	FGF10	SERPINE1	*COL1A1*	*COL1A1*	*COL1A1*
TIMP2	COL5A1	COL5A1	ITGA5	PLAUR	*COL1A1*	TGFB2	COL4A1	EXT1	IRF1