Pathologies of PPARδ null placentas.
(A) Mouse PPARδ tissue blot. Note the
high PPARδ levels in two different stages of placental
development (E10.5, E13.5), superior to most tissues, except kidney.
(B and C) wt and PPARδ
null placentas at E9.5. Arrows in C denote the abnormal
detachment of the PPARδ null placenta from the
decidua. (D and E) wt and
PPARδ null placentas at E12.5. The inner core of the
mutant placenta contains a massive maternal hematoma (MH) and is
completely devoid of trophoblast cells. (F and
G) wt and PPARδ null placentas at
E14.5. The mutant placenta is surrounded by a maternal hematoma (MH).
De, decidua; Sp, spongiotrophoblast layer; La, placental labyrinth; Th,
thrombus. (Magnifications: B and C: ×20;
D and E: ×11; F and
G: ×7.)