Figure 3.

Compromised adipose stores in PPARδ mutants. (A and B) Abdominal fat depots of wt (A) and PPARδ null mice (B), exhibiting a substantial compromise in the amount of fat tissue in a null mouse. (C and D) At 4 months the pericardial white fat depots are routinely found in wt mice (arrow in C) but absent from PPARδ null ones (D). (E and F) Hematoxylin and eosin-stained paraffin sections of skin from the lower back of wt (E) and PPARδ null mice (F). The subcutaneous fat layer is dramatically shrunk in the mutant, reflecting a combined effect of reduced adipocyte number and size. (Magnifications: E and F: ×15.)