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. 2024 Nov 18;74(2):223–233. doi: 10.2337/db24-0340

Figure 1.

Figure 1

C-Peptide meta-GWAS. A: Manhattan plot. B: Q-Q plot. C: HLA locus (TOPMed imputation). D: GABRG2 locus. E: HLA region (HLA imputation). F: HLA region conditional to HLA-DQB1*06:02. The plots in A–D were made using LocusZoom (https://my.locuszoom.org/). The LD is based on the European population from the 1000 Genomes LD panel derived from deep whole-genome sequencing (50). The coordinates are based on GRCh38. The plots in E and F were made using HLAManhattan in HLA-TAPAS (https://github.com/immunogenomics/HLA-TAPAS) (31). HLA haplotypes, AA changes, and SNPs/indels are in red, yellow, and gray, respectively. The coordinates are based on GRCh37.