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. 2024 Nov 18;74(2):223–233. doi: 10.2337/db24-0340

Figure 2.

Figure 2

AAD meta-GWAS. A: Manhattan plot. B: Q-Q plot. C: CTSH locus. D: HLA-DR-DQ locus. E: HLA-A locus. F: HLA region (HLA imputation). G: HLA region conditional to HLA-DQB1*03:02. H: HLA region conditional to HLA-DQB1*03:02 and HLA-DRB1*03:01. I: HLA region conditional to HLA-DQB1*03:02, HLA-DQB1*03:02, and HLA-A*24:02:01:01. The plots in A–E were made using LocusZoom (https://my.locuszoom.org/). The LD is based on the European population from 1000 Genomes LD panel derived from deep whole-genome sequencing (50). The coordinates are based on GRCh38. The plots in F and G were made using HLAManhattan in HLA-TAPAS (https://github.com/immunogenomics/HLA-TAPAS) (31). HLA haplotypes, AA changes/indels are in red, yellow, and gray, respectively. The coordinates are based on GRCh37.