Table 1.
HLA haplotypes associated with C-peptide or AAD
| Haplotype | bp (HG19) | Freq | Effect | SE | P | Direction* | Het I2 | Het P |
|---|---|---|---|---|---|---|---|---|
| C-peptide | ||||||||
| HLA-DQB1*06:02:01:01 | 32,627,324 | 0.01 | 0.90 | 0.11 | 1.18E-16 | + + + + | 79.00 | 2.52E-03 |
| HLA-DRB1*15:01:01:01 | 32,546,786 | 0.01 | 0.70 | 0.10 | 1.68E-12 | + + + + | 85.10 | 1.55E-04 |
| AAD | ||||||||
| HLA-DQB1*03:02:01:01 | 32,627,261 | 0.29 | −0.26 | 0.03 | 1.76E-24 | − − − − − | 84.20 | 4.30E-05 |
| HLA-DQA1*02:01:01:01 | 32,605,195 | 0.07 | 0.33 | 0.04 | 3.81E-14 | + − + + + | 86.50 | 5.62E-06 |
| HLA-DRB1*15:01:01:01 | 32,546,786 | 0.02 | 0.66 | 0.09 | 6.07E-14 | + + + + + | 62.10 | 3.20E-02 |
| HLA-DQB1*06:02:01:01 | 32,627,324 | 0.01 | 0.71 | 0.09 | 8.74E-14 | + + − ? + | 79.90 | 1.91E-03 |
| HLA-DRB1*07:01:01:01 | 32,546,630 | 0.07 | 0.32 | 0.04 | 3.56E-13 | + − + + + | 83.70 | 6.19E-05 |
| HLA-DQA1*03:01:01 | 32,605,198 | 0.37 | −0.17 | 0.02 | 1.54E-12 | − − − + − | 63.80 | 2.59E-02 |
| HLA-DQB1*03:01:01:01 | 32,627,258 | 0.09 | 0.26 | 0.04 | 1.01E-11 | + + − + + | 58.50 | 4.68E-02 |
| HLA-DQA1*01:02:01:01 | 32,605,187 | 0.07 | 0.27 | 0.04 | 3.41E-11 | + + + − + | 84.40 | 3.74E-05 |
| HLA-A*24:02:01:01 | 29,910,454 | 0.09 | −0.22 | 0.04 | 5.18E-10 | − − − − − | 14.80 | 3.20E-01 |
| HLA-DRB1*04 | 32,546,587 | 0.33 | −0.15 | 0.03 | 1.14E-09 | − − − − − | 51.20 | 8.45E-02 |
| AAD conditional to HLA-DQB1*03:02 | ||||||||
| HLA-DRB1*03:01:01:01 | 32,546,570 | 0.32 | −0.18 | 0.02 | 6.73E-15 | − − − + − | 65.80 | 1.99E-02 |
| AAD conditional to HLA-DQB1*03:02 and HLA-DRB1*03:01 | ||||||||
| HLA_A*24:02:01:01 | 29,910,454 | 0.09 | −0.27 | 0.04 | 3.08E-14 | − − − − − | 6.56 | 1.61E-01 |
Freq, frequency; Het, heterogeneity.
*The order of studies for C-peptide analysis is SDRNT1BIO, DCCT, CACTI, and WESDR, and for AAD, the order is SDRNT1BIO, DCCT, CACTI, EDC, and WESDR.