Metha 2010.

Methods	Randomised cross‐over trial.
Participants	Neonates born at <31 weeks' gestation and expected to have at least 2 examinations for ROP.
Interventions	Proparacaine HCl ophthalmic solution 0.5% or NaCl 0.9% (saline) eye drops.
Outcomes	Pain assessed by PIPP.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated block randomisation.
Allocation concealment (selection bias)	Low risk	Only pharmacist was aware of allocation.
Blinding (performance bias and detection bias) All outcomes	Low risk	Neither physician nor nurse recording score was aware of treatment group.
Incomplete outcome data (attrition bias) All outcomes	Low risk	10 patients did not have both examinations.
Selective reporting (reporting bias)	Low risk

PIPP: Premature Infant Pain Profile 
 ROP: retinopathy of prematurity