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. 2025 Jan 24;15:3020. doi: 10.1038/s41598-025-87525-3

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — The general overview of proteomic expression in astrocytoma tissue. (A) Principal component analysis of the data distribution of astrocytoma with seizure and without seizure. (B) Volcano plot of differentially expressed protein between seizure and non-seizure astrocytoma tissue. Red: significant change between astrocytoma with seizure and without seizure, green and black: no significant change between astrocytoma with seizure and without seizure. (C) An intensity heatmap top 10 predominantly upregulated and downregulated proteins from astrocytoma tissue with and without seizure. Barplot indicates the tumor volume in cm³ in each sample.