Table 3. Study status.

Version	Date	Changes made	Reason for changes
1	February 13, 2024	Initial submission as registered report to PLOS Biology and PLOS ONE (not accepted)	Initial version Link to initial version: https://nxc-fredato.imbi.uni-freiburg.de/s/o6TsmZBMdngtamp
2	August 09, 2024	Clarify data used for the hypotheses; some minor text changes (no methodological changes)	Hypotheses align to conclusions in Nearing et al.; make some sentences more precise Link to version with edits: https://nxc-fredato.imbi.uni-freiburg.de/s/jSRNoQxYzk5E6LW
3	August 13, 2024	Change order and naming of sections	Naming of protocoll sections need to align with F1000 requirements Link to version with edits: https://nxc-fredato.imbi.uni-freiburg.de/s/j5ibzbXMwW3Ssj9
4	December 17, 2024	Change abstract and update study setting, Add more information about data generating mechanism in intervention description {11a}, In explanation for the choice of comparators {6b} add procedure to eliminate highly correlated DC, Clarify hypotheses for aim2, Extend discussion In table 5 add three data characteristics	Address comments in revision Link to version with edits: https://nxc-fredato.imbi.uni-freiburg.de/s/wD34Ge6mYtkxWrB

Summary of all protocol versions and the corresponding changes.