Table 5.
Co-occurrence between keywords related to internal exposomes and health event categories among the articles published between 1975 and 2024. Each cell refers to the number of times (%) a keyword related to an exposome category (eg, chemical agent) was mentioned among all publications in which a keyword related to a health event category (eg, cancer) appeared (N=296). Please note that the absolute value for each row is provided in parentheses with the row header and remains the same for all the parameters in that row.
| Health event, n | Internal exposome (%) | ||||||||||
|
|
Age | Sex | BMI | BPa | Heredity | Ethnicity | Hormone | Menopause | Metabolism | OSb | Inflammation |
|
| |||||||||||
| Cardiovascular disease (n=17) | 5.88 | 11.8 | 5.88 | 5.88 | 0 | 5.88 | 0 | 0 | 0 | 0 | 0 |
| Work-related disease (n=5) | 0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Autoimmune disease (IBDc, RAd, vasculitis, and NRe; n=9) | 0 | 0 | 11.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cancer (n=150) | 3.62 | 27.5 | 2.17 | 0 | 0.73 | 1.45 | 3.62 | 0.73 | 2.9 | 0.73 | 0 |
| Dental health (n=2) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Ocular disorder (n=6) | 16.7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Frailty (n=2) | 50 | 0 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Anemia (n=1) | 100 | 100 | 0 | 0 | 0 | 0 | 0 | 0 | 100 | 0 | 0 |
| Infectious disease (malaria, Lyme disease, tuberculosis, toxoplasmosis, and NR; n=14) | 0 | 7.14 | 0 | 0 | 0 | 7.14 | 0 | 0 | 0 | 0 | 0 |
| Injury (including workplace accident and disability; n=40) | 4.26 | 8.51 | 2.13 | 0 | 0 | 2.13 | 0 | 2.13 | 0 | 0 | 0 |
| Chronic kidney disease (n=3) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mental health disorder (depression, suicide, and NR; n=25) | 9.52 | 4.76 | 4.76 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Metabolic disorder (diabetes, dysthyroidism, and NR; n=9) | 11.1 | 0 | 11.1 | 11.1 | 0 | 11.1 | 0 | 0 | 0 | 0 | 0 |
| Mortality (n=75) | 4.17 | 17.7 | 0 | 0 | 1.04 | 0 | 1.04 | 2.08 | 0 | 0 | 0 |
| Musculoskeletal disorder (arthritis, low-back pain, and NR; n=14) | 7.14 | 14.3 | 7.14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Neurodegenerative disease (ADf, ALSg, MNDh, MSi, PDj, and NR; n=33) | 6.06 | 0 | 0 | 0 | 3.03 | 6.06 | 0 | 0 | 12.1 | 6.06 | 0 |
| Sensory impairment (n=1) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Reproductive disorder (birth defects, infertility, spontaneous abortion, and NR; n=24) | 0 | 28.6 | 14.3 | 0 | 0 | 7.14 | 7.14 | 0 | 7.14 | 0 | 0 |
| Respiratory disorder (allergy, asthma, COPDk, pneumonia, sarcoidosis, and NR; n=39) | 5.88 | 11.8 | 8.82 | 2.94 | 0 | 5.88 | 0 | 0 | 5.88 | 0 | 2.94 |
| Skin disorder (dermatitis and NR; n=2) | 0 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
aBP: blood pressure.
bOS: oxidative stress.
cIBD: inflammatory bowel disease.
dRA: rheumatoid arthritis.
eNR: not reported.
fAD: Alzheimer disease.
gALS: amyotrophic lateral sclerosis.
hMND: motor neuron disease
iMS: multiple sclerosis.
jPD: Parkinson disease.
kCOPD: chronic obstructive pulmonary disease.