Figure 5.

Thalamocortical circuits proposed to subserve temporal binding; diagram of the two thalamocortical systems. The first loop shows the specific ventrobasal nucleus projecting to layer IV of the cortex and to inhibitory interneurons and collaterally to reticular nucleus and striatum/putamen. The second loop shows the nonspecific centrolateral intralaminar nucleus projecting to layers I and VI and also giving collaterals to reticular nucleus and striatum/putamen. Collaterals of these two thalamocortical projections also produce thalamic feedback inhibition via the reticular nucleus and globus pallidus (GPi). The return pathway (in brown) from deep layers V–VI returns the oscillation to the thalamic reticular, ventrobasal, and centrolateral nuclei.