. 2025 Feb 19;15(2):99996. doi: 10.5498/wjp.v15.i2.99996

Table 2.

Comparison of clinical manifestations at baseline and follow-up outcomes between major depressive disorders patients with high-level and low-level stress-sensitivity factors

Items	Groups	HAMD-17 at baseline	HAMD-17 at the end of follow-up	HAMA at baseline	HAMA at the end of follow-up	BSSI at baseline	BSSI at the end of follow-up (n = 66)	SDS at baseline	SDS at the end of follow-up	PDQ-5 at baseline	PDQ-5 at the end of follow-up
Neuroticism	Low-level	20.88 ± 5.42	9.54 ± 6.56	20.75 ± 7.65	10.31 ± 7.31	6.92 ± 7.04	4.23 ± 5.77	17.28 ± 6.01	10.90 ± 7.34	11.35 ± 3.47	7.34 ± 4.20
	High-level	22.10 ± 4.86	14.11 ± 7.46	22.83 ± 7.12	14.97 ± 7.87	10.74 ± 8.46	8.55 ± 8.64	21.35 ± 4.74	14.31 ± 7.68	13.11 ± 3.40	10.49 ± 4.75
	Sig.	0.070	0.002^a	0.024^a	0.003^a	0.003^a	0.044^a	< 0.001^a	0.035^a	0.001^a	0.001^a
Trait anxiety	Low-level	20.08 ± 5.05	9.17 ± 6.38	20.00 ± 6.94	9.95 ± 6.46	6.44 ± 6.21	4.19 ± 5.13	17.52 ± 6.18	10.79 ± 7.12	11.51 ± 3.61	7.38 ± 4.17
	High-level	24.76 ± 4.33	15.97 ± 6.88	25.55 ± 7.84	16.83 ± 8.98	13.04 ± 9.46	9.61 ± 9.86	21.49 ± 3.97	15.23 ± 7.99	13.02 ± 3.06	10.91 ± 4.79
	Sig.	< 0.001^a	< 0.001^a	< 0.001^a	< 0.001^a	< 0.001^a	0.038^a	< 0.001^a	0.005^a	0.008^a	< 0.001^a
Perceived stress	Low-level	20.08 ± 5.13	10.26 ± 7.05	20.00 ± 7.01	10.67 ± 7.45	6.76 ± 7.15	4.84 ± 5.80	17.48 ± 5.97	11.28 ± 7.35	11.36 ± 3.50	7.78 ± 4.59
	High-level	24.07 ± 4.54	12.44 ± 7.17	24.72 ± 7.80	14.23 ± 7.99	11.27 ± 8.04	7.32 ± 9.09	21.00 ± 5.16	13.47 ± 8.00	13.15 ± 3.31	9.50 ± 4.40
	Sig.	< 0.001^a	0.132	< 0.001^a	0.023	< 0.001^a	0.253	< 0.001^a	0.155	0.001^a	0.063
State anxiety	Low-level	20.41 ± 5.13	10.23 ± 6.91	20.33 ± 7.44	10.59 ± 6.93	6.82 ± 6.89	5.20 ± 6.08	17.59 ± 6.04	11.38 ± 7.39	11.52 ± 3.59	7.80 ± 4.48
	High-level	23.98 ± 4.87	13.11 ± 7.50	24.81 ± 6.89	15.42 ± 9.23	12.19 ± 8.71	6.75 ± 9.11	21.50 ± 4.58	13.70 ± 8.04	13.08 ± 3.09	9.87 ± 4.66
	Sig.	< 0.001^a	0.064	< 0.001^a	0.017	< 0.001^a	0.418	< 0.001^a	0.162	0.007^a	0.038

P values that survived false discovery rate correction for multiple testing.

HAMD-17: 17-item Hamilton Depression Scale; HAMA: Hamilton Anxiety Scale; BSSI: Beck Scale for Suicide Ideation; SDS: Sheehan Disability Scale; PDQ-5: Perceived Deficits Questionnaire five-item version.