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Rapamycin prevents BDNF-induced synaptic potentiation in hippocampal slices. Shown are ensemble averages for all control and rapamycin experiments. BDNF (50 ng/ml) was applied in the ACSF at the time indicated by the bar. Mean control fEPSP slope values were 0.13 ± 0.03 mV/msec before BDNF application and 0.23 ± 0.04 mV/msec after BDNF application. Mean rapamycin-treated fEPSP slope values were 0.16 ± 0.01 mV/msec before BDNF application and 0.18 ± 0.01 mV/msec after BDNF application.
