Fig. 1.

Humoral and cellular specific SARS-CoV-2 response after vaccination. Bar graphs representing anti-S IgG levels after vaccination in paediatric and adolescent heart transplant recipients (red; n = 12) and healthy controls (green; n = 14) (A). Dot plots representing the percentage of SARS-CoV-2 specific T-cell response (left) and rate of responders (right) within total and memory (CD45RA⁻) CD4⁺ and CD8⁺ T-cell comparing heart transplant recipients and healthy controls after vaccination (B). Bar graphs representing anti-S IgG levels after vaccination in paediatric and adolescent participants with previous SARS-CoV-2 infection (purple; n = 16) and without previous infection (orange; n = 10) (C). Dot plots representing the percentage of SARS-CoV-2 specific T-cell response (left) and rate of responders (right) within total and memory (CD45RA⁻) CD4⁺ and CD8⁺ T-cell comparing participants with previous SARS-CoV-2 infection and without previous infection (D). For C and D HTR and HC have been represented by squares and triangles, respectively. Abbreviation: HTR, heart transplant recipients; HC, healthy controls. Continuous variables were compared using Mann-Whitney U test and rate of responders using X² test. #0.05≤p-value<0.1; ∗p-value<0.05; ∗∗p-value<0.01. Only statistical p-value <0.1 is shown.