Table 2.
HFE genotypes for codon 282 of HCC cases and control cohorts. Ages in years and numbers (percentages) of cases with each genotype.
| HCC Patients | Controls * | ||
| Mean Age | 54 a | 57 | |
| CC (normal) | 119 (82.6%) | 1331 (88.2%) | |
| CY (heterozygotes) | 17 (11.8%) | 168 (11.1%) | p = 0.34 |
| YY (homozygotes) | 8 (5.6%) | 9 (0.6%) | p = 0.00003 |
| Total Number | 144 | 1508 | |
p values are single tailed probabilities of over-representation of mutant genotypes in HCC patients by Fisher's exact test.
* Norfolk data presented in Willis et al. 2002 [12], Cambridge data presented in Halsall et.al. 2003 [14].
a age data available for only 138/144 cases.