Table 5.

Hippocampal Volume and DNA Methylation Interactions With Age and Sex

	NR3C1		FKBP5		SLC6A4
	Beta	p	Beta	p	Beta	p
Age Interaction
PC1	−5.813	2.14 × 10−5a	−4.755	2.14 × 10−4a	4.786	2.35 × 10−4a
Age (in years)	0.823	<2 × 10−16a	0.852	<2 × 10−16a	0.832	<2 × 10−16a
PC1 × age	0.602	5.72 × 10−16a	0.595	3.09 × 10−16a	−0.571	1.43 × 10−13a
Sex Interaction
PC1	−6.588	2.98 × 10−5a	−3.355	.026a	5.811	6.84 × 10−5a
Sex	1.809	5.02 × 10−5a	1.859	4.87 × 10−5a	1.714	1.30 × 10−4a
PC1 × sex	0.085	.853	0.113	.806	0.210	.659

DNA methylation is represented by first principal components (PC1). Covariates include age at scan, sex, days between genetic collection and brain scan, cell count, batch, and position. Interactions reported with age as a continuous variable.

^aIndicates significant p value (< .05).