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. 2025 Jan 10;55(3):45. doi: 10.3892/ijmm.2025.5486

Figure 5.

Figure 5

Klotho regulates EMT of ARPE-19 cells via the ERK1/2 and Wnt/β-catenin signaling pathway. Protein expression levels of (A) ERK signaling pathway were analyzed using western blotting. (B) Relative protein expression. (C) β-catenin pathway were analyzed using western blotting. (D) Quantification of the relative protein expression of β-catenin. (E) Quantification of the relative protein expression of c-Myc. (F) Quantification of the relative protein expression of CyclinD1 (normalized to GAPDH) in western blot. *P<0.05, **P<0.01, ***P<0.001. EMT, epithelial-mesenchymal transition; Lv, lentiviral vector; NC, negative control; p, phosphorylated.