Table 2.
Parameter | Group | Basal | Endotoxemia | |||
30 min | 60 min | 90 min | 120 min | |||
Hemoglobin (g/l) | Sham | 9.6 ± 2.4 | 9.7 ± 2.7 | 9.9 ± 2.3 | 9.8 ± 2.2 | 9.9 ± 2.2 |
Normal | 9.1 ± 2.3 | 9.0 ± 2.4 | 8.4 ± 2.0* | 8.1 ± 2.2* | 8.3 ± 2.4* | |
Increased | 8.9 ± 2.2 | 8.2 ± 2.3* | 7.8 ± 2.4* | 7.6 ± 2.5* | 7.7 ± 2.5* | |
pH | Sham | 7.44 ± 0.03 | 7.45 ± 0.02 | 7.45 ± 0.03 | 7.47 ± 0.02 | 7.47 ± 0.03 |
Normal | 7.39 ± 0.07 | 7.34 ± 0.08*† | 7.31 ± 0.05*† | 7.34 ± 0.05*† | 7.35 ± 0.06*† | |
Increased | 7.42 ± 0.04 | 7.35 ± 0.05*† | 7.31 ± 0.05*† | 7.28 ± 0.08*† | 7.25 ± 0.08*†‡ | |
PCO2 (mmHg) | Sham | 35 ± 3 | 34 ± 3 | 34 ± 3 | 33 ± 3 | 34 ± 4 |
Normal | 35 ± 4 | 38 ± 6* | 41 ± 7* | 37 ± 6 | 35 ± 6 | |
Increased | 34 ± 2 | 36 ± 5 | 34 ± 3 | 34 ± 5 | 37 ± 6 | |
PO2 (mmHg) | Sham | 85 ± 13 | 88 ± 18 | 86 ± 16 | 88 ± 17 | 84 ± 15 |
Normal | 87 ± 16 | 119 ± 59 | 105 ± 39 | 123 ± 20*† | 134 ± 43*† | |
Increased | 90 ± 23 | 150 ± 48*† | 132 ± 21*† | 101 ± 20 | 99 ± 31 | |
[HCO3-] (mmol/l) | Sham | 24 ± 2 | 24 ± 3 | 24 ± 3 | 24 ± 3 | 24 ± 3 |
Normal | 21 ± 2 | 21 ± 2 | 20 ± 2† | 20 ± 2*† | 19 ± 2*† | |
Increased | 22 ± 3 | 20 ± 2*† | 17 ± 3*† | 16 ± 3*†‡ | 16 ± 2*†‡ | |
Base excess (mmol/l) | Sham | 1 ± 3 | 1 ± 3 | 1 ± 3 | 2 ± 3 | 2 ± 3 |
Normal | t2 ± 4 | t5 ± 3*† | t5 ± 2*† | t5 ± 3*† | t5 ± 3*† | |
Increased | t1 ± 4 | t4 ± 3*† | t8 ± 4*† | t10 ± 4*† | t10 ± 3*†‡ | |
[Cl-]/[Na+] | Sham | 0.76 ± 0.02 | 0.76 ± 0.03 | 0.76 ± 0.03 | ||
Normal | 0.76 ± 0.01 | 0.77 ± 0.02 | 0.77 ± 0.01 | |||
Increased | 0.76 ± 0.02 | 0.78 ± 0.02* | 0.80 ± 0.02*†‡ | |||
Lactate (mmol/l) | Sham | 2.1 ± 0.7 | 2.0 ± 0.7 | 1.8 ± 0.6 | ||
Normal | 1.7 ± 0.8 | 1.9 ± 0.7 | 2.2 ± 1.1 | |||
Increased | 2.2 ± 1.6 | 1.7 ± 1.1 | 1.9 ± 1.1 |
* P < 0.05 versus basal. † P < 0.05 versus sham. ‡ P < 0.05 versus normal. Sham, sham group; normal, normal blood flow group; increased, increased blood flow group.