Table 2. Clinical and laboratory outcomes according to intervention arm.

Variable	Control groupN=24	Intervention groupN=25	Difference in means (95% CI)	P value
Duration of diarrhoea; time to (hours)*
Last watery/loose stool	24; 38.7 (22.0)	25; 19.6 (15.5)	−19.3 (−30.9 to −7.8)	0.0016
First formed stool	24; 49.3 (23.1)	24; 31.1 (14.5)	−16.6 (−28.5 to −4.7)	0.0075
No. watery stools
0–4 hours	23; 0.7 (0.9)	24; 0.6 (0.7)	0.0 (−0.5 to 0.5)	>0.99
Day 2	23; 2.4 (1.2)	24; 1.6 (0.9)	−0.8 (−1.3 to −0.3)	0.0022
Day 3	23; 1.3 (1.0	24; 0.5 (0.8)	−0.8 (−1.3 to −0.3)	0.0014
Day 4	13; 0.9 (0.9)	2; 0.0 (0.0)	−1.0 (−2.3 to 0.3)	0.13
Day 5	1; 2.0 (−)	0; −	–	–
Volume of study treatment taken 0–4 hours*
mL/kg	25; 26.7 (14.7)	25; 25.6 (14.0)	1.2 (−4.2 to 6.6)	0.65
% prescribed	25; 92.3 (18.7)	25; 93.0 (30.6)	4.7 (−9.0 to 18.4)	0.49
Change in weight 0–4 hours (kg)	25; 0.20 (0.44)	25; 0.57 (0.65)	0.29 (−0.23 to 0.80)	0.28
Volume of study treatment taken in phase 2 (cups)
Day 2	23; 3.1 (0.8)	25; 3.3 (0.7)	0.2 (−0.3 to 0.7)	0.51
Day 3	24; 1.8 (1.1)	25; 2.3 (0.9)	0.5 (0.0 to 1.0)	0.07
Day 4	13; 1.8 (0.8)	2; 1.0 (0.0)	−0.8 (−2.1 to 0.5)	0.23
Day 5	1; 3.0 (−)	0; −	–	–
Laboratory indices: change between baseline and 4 hours*
Haemoglobin (g/L)	21; −0.3 (1.0)	21; −0.2 (0.9)	0.2 (−0.3 to 0.8)	0.43
Sodium (mmol/L)	21; 1.3 (3.2)	21; 0.2 (2.0)	−1.3 (−3.0 to 0.3)	0.11
Potassium (mmol/L)	21; 0.1 (1.5)	21; 0.0 (0.4)	−0.4 (−1.0 to 0.2)	0.20
Creatinine (μmol/L)	21; −0.4 (2.1)	20; −4.2 (19.9)	0.3 (−0.7 to 1.4)	0.52

All values are number; mean (SD).

Statistically significant differences are shown in bold type.

^*aAdjusted for age, sex, time from diarrhoea onset to randomisation, and hydration status.