Table 3.

Proteins in the top quartile of expression in lung cells were mapped to the human protein-protein interactome using STRING.

term	p-value	q-value
Methimazole	0.0004	0.0189
Sirolimus	0.0035	0.0633
Progesterone	0.0059	0.0787
Cetirizine	0.0077	0.0787
Nafamostat	0.0169	0.0787
Decitabine	0.0184	0.0787
Didanosine	0.0200	0.0787
Methylprednisolone	0.0245	0.0787
Propylthiouracil	0.0260	0.0787
Flutamide	0.0306	0.0787
Cladribine	0.0321	0.0787
Prednisolone	0.0396	0.0821

The full set of proteins comprising the STRING network (Table S4) were used as inputs into Enrichr to query the Multi-marker Analysis of GenoMic Annotation (MAGMA) drugs and diseases database, which identified drugs that would target enriched pathways represented by the proteins associated with FEV₁/FVC in both the Alpha-1 Genetic Modifiers Study and COPDGene.