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Autophagic vacuoles are prominent in runx1 mutant denervated myofibers. The vacuoles in runx1 mutant denervated (14-d) muscle (MCK::cre; runx1f/f) are enclosed by two bilayers (arrows) that enclose heterogeneous contents, including mitochondria (a), myofibrils (b), and other membrane-enclosed structures (c,d), hallmark features of autophagic vacuoles (Gozuacik and Kimchi 2004). (*) Autophagic vacuoles; (M) mitochondrion. Bar, 0.12 μm.
