Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2025 Jan 10;12:1530644. doi: 10.3389/fcell.2024.1530644

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2025 Sun, Zhong, Yu, Luo, Ren, Liu, Chen, Flores-Borja, Sun and An.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Ccrl2 ⁺ Macrophages are significantly affected by aging. (A) Segmentation of the myeloid cells population (Cluster 0) into three distinct clusters: SC0, SC1 and SC2, showing marked upregulation of Cdkn1a in SC0 and SC2. (B) DEG analysis identifies Ccrl2 as one of the top upregulated gene in SC0 and SC2 myeloid cells in aged pulp compared to young adults. (C) UMAP and Violin plot analysis illustrated the differential expression of Ccrl2. (D) Dot plot showing the expression patterns of cell-type-enriched marker genes across the three subclusters.