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. 2025 Jan 24;25:139. doi: 10.1186/s12885-025-13566-6

Table 3.

Cox proportional hazards regression models for OS and PFS in the entire study population with organ-specific irAEs

Toxicity OS, Univariable OS, Multivariable PFS, Univariable PFS, Multivariable
HR (95% CI) P HR (95% CI) P HR (95% CI) P HR (95% CI) P
Skin toxicity 0.33 (0.13–0.81) 0.016 0.39 (0.16–0.96) 0.040 0.43 (0.24–0.80) 0.008 0.43 (0.23–0.80) 0.008
Endocrine toxicity 0.20 (0.05–0.79) 0.022 0.18 (0.04–0.74) 0.018 0.52 (0.26–1.06) 0.073 0.48 (0.24–0.99) 0.046
Bone and joint and muscle toxicity 1.89 (0.60–5.96) 0.279 2.40 (0.74–7.80) 0.147 1.59 (0.59–4.30) 0.359 1.92 (0.70–5.22) 0.204
Pulmonary toxicity 0.89 (0.45–1.77) 0.738 0.65 (0.30–1.41) 0.279 1.10 (0.67–1.82) 0.706 0.95 (0.56–1.62) 0.841
Cardiotoxicity 0.78 (0.25–2.47) 0.677 0.72 (0.22–2.31) 0.575 0.76 (0.34–1.72) 0.506 0.67 (0.29–1.55) 0.351
Digestive system toxicity 0.65 (0.21–2.05) 0.461 0.68 (0.21–2.16) 0.511 0.83 (0.39–1.76) 0.618 0.84 (0.39–1.79) 0.649
Renal toxicity 1.88 (0.46–7.63) 0.379 2.50 (0.60-10.42) 0.208 0.83 (0.21–3.34) 0.790 0.99 (0.24–4.04) 0.987

OS: overall survival; PFS: progression-free survival; HR: hazard ratio; irAEs: immune-related adverse events