Table 1.

Provides a detailed overview of the N- and C-terminal domains, highlighting the specific functions associated with each TRP subfamily.

	N-terminal	C-terminal	Function	Ref
TRPA	Ankyrin binding domain	–	Thermosensitivity, Nociception	9, 10
TRPC	Ankyrin binding domain	TRP box, Homer, calmodulin, IP3R, PDZ domain	Blood pressure regulation, angiogenesis	11, 12
TRPM	TRPM homology region (MHR) domain	TRP box, calmodulin, IP3R, α-kinase, ADP-ribose hydrolase	Core body temperature sensation, inflammatory pain, cold sensation	13, 14, 15
TRPML	Nuclear localization domain	EF-hand, Late endosomal/lysosomal targeting signal	Immune response, cell depolarization	16, 17
TRPP	GSK3 phosphorylation site, Cilial transport motif	EF-hand, ER retention signal, coiled-coil domain	Calcium signaling	18, 19
TRPV	Ankyrin binding domain	PIP2, PDZ domain, calmodulin	Neurodepolarization, Thermosensitivity, Mechanosensitivity	20, 21, 22