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. 2024 Nov 12;7(2):101268. doi: 10.1016/j.jhepr.2024.101268

Table 3.

Cox regression analysis for incidence of hepatocellular carcinoma.

Characteristics Univariable
Multivariable
Hazard ratio (95% CI) p value Hazard ratio (95% CI) p value
Antiviral agents
 TAF 1 (ref) 1 (ref)
 TDF 1.285 (1.148-1.439) <0.001 1.335 (1.193-1.495) <0.001
 ETV 1.115 (0.993-1.252) 0.066 1.162 (1.034-1.306) 0.011
Age (years) 1.042 (1.037-1.046) <0.001 1.041 (1.037-1.046) <0.001
Male 2.239 (2.019-2.482) <0.001 2.496 (2.247-2.773) <0.001
Duration of antiviral medication (days) 1.000 (1.000-1.001) <0.001 1.000 (1.000-1.001) <0.001
Presence of liver cirrhosis 4.373 (3.997-4.785) <0.001 3.102 (2.819-3.413) <0.001
Decompensated cirrhosis 2.865 (2.534-3.239) <0.001 1.627 (1.430-1.850) <0.001
Charlson Comorbidity Index score 0.975 (0.944-1.006) 0.110

p values were evaluated using Cox regression analysis. ETV, entecavir; TAF, tenofovir alafenamide; TDF, tenofovir disoproxil fumarate.