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Effect of W-13 on 125I-EGF internalization, recycling and degradation. COS-1 cells were incubated, in the presence of 10 μg/ml W-13 (○) or vehicle DMSO (●), with 1–5 ng/ml 125I-EGF for 1–10 min or 1–60 min to measure internalization (D) or downregulation (A), recycling (B), or degradation (C). The amount of surface-bound, internalized, or intact radioactivity in the medium was determined as described in MATERIALS AND METHODS.
