Table 2.
Frequency of association of specific chromosomal bands with stress-induced SNBs
Chromosome | Probe | Association with
stress-induced SNBs (percentage of cells)
|
||
---|---|---|---|---|
+ | − | n | ||
9 | Sat III | 75a | 25 | 279 |
12 | Sat α | 70b | 30 | 64 |
15 | Sat α | 80c | 20 | 58 |
X | Sat α | 24d | 76 | 96 |
Stress-induced SNBs and interphase territories were labeled, optical sections through whole nuclei were collected at 0.5 μm intervals, and overlap between the stress-induced SNBs and signals obtained with satellite specific probes was scored as (+) or (−). The assignment to either (+) or (−) classes was independently done by two individuals. The number of cells (n) analysed as indicated.
Probability of a specific association between HSA9 and stress- induced SNBs: χ21 = 69.25; P << 0.0001.
Probability of a specific association between HSA12 and stress-induced SNBs: χ21 = 12.65; P << 0.0001.
Probability of a specific association between HSA15 and stress-induced SNBs: χ21 = 30.37; P << 0.0001.
Probability of a random association between X chromosome and stress-induced SNBs: χ21 = 24.04; P << 0.0001.