Table 2.
Characteristics of the 25 patients included in the real-life implementation analysis in terms of adherence, relative forgiveness (RF) and outcomes
| All patients (n = 25) |
Group 1 (RF ≥ 0.32) (n = 19) |
Group 2 (RF < 0.32) (n = 6) |
Comparison between the two groups (significance)a | |
|---|---|---|---|---|
| Allopurinol dose (mg)b | 300 (100–600) | 300 (100–600) | 300 (100–600) | 1 |
| Adherence data | ||||
| Total number of missed doses | 1237 | 399 | 838 | < 0.0001 |
| Median number of missed doses per person | 33 | 19 | 118 | |
| Total number of non-implementation eventsd | 675 | 298 | 377 | |
| Occasional missed doses (n) | 108 | 98 | 10 | < 0.0001 |
| Repeated missed doses (n) | 482 | 186 | 296 | < 0.0001 |
| Occasional drug holidays (n) | 5 | 5 | 0 | – |
| Repeated drug holidays (n) | 80 | 9 | 71 | < 0.0001 |
| Proportion of doses taken | 91% | 95% | 67% | < 0.0001 |
| Relative forgiveness of implementation patternsb | ||||
| Relative forgiveness | 0.51 (0–1) | 0.61 (0.32–1) | 0.16 (0–0.26) | 0.0003 |
| Outcomesb | ||||
| Proportion of days at the urate target | 75% | 86% | 41% | 0.001 |
| Flares | ||||
| Total number | 18 | 10 | 8 | OR = 4.3e [95% CI 0.6–30.6] |
| Mean number of flares per person | 0.7 | 0.5 | 1.3 | 0.129 |
| HRQoL utility scores | 0.9459 | 0.9456 | 0.9464 | 0.838 |
| EQ-VAS scores | 80.0 | 80.0 | 81.3 | 0.873 |
RF = relative forgiveness; OR = odds ratio; CI = confidence interval; occasional missed doses = ≤ 2 consecutive missed doses followed by ≥ 15 consecutive doses taken as prescribed; repeated missed doses = ≤ 2 consecutive missed doses followed by < 15 consecutive doses taken as prescribed; occasional drug holidays = ≥ 3 consecutive missed doses followed by ≥ 15 consecutive doses taken as prescribed; repeated drug holidays = ≥ 3 consecutive missed doses followed by < 15 consecutive doses taken as prescribed; HRQoL = health related quality of life; EQ-VAS = EuroQoL-visual analog scale
ap-value of Mann–Whitney test unless otherwise stated
bMedian (range) unless otherwise specified
cp-value of Fisher’s exact test
dA non-adherence event is any instance of an occasional missed dose, repeated missed dose, repeated missed dose or repeated missed dose throughout the study period
eOdds of having at least one flare in subgroup 2