Table 2.
Examples of single nucleotide polymorphisms (SNPs) that increase the risk of developingmultiple primary cancers
| PMID/DOI | SNP/Gene | Major component cancers |
|---|---|---|
| 36199081 |
rs7872034/SMC2 rs143745791/NCBP1 |
Breast cancer with other cancer |
| 36199081 | rs141647689 |
Bladder Cancer Prostate Cancer |
|
rs535484207 rs139586367 rs191064896 |
Lymphoid Neoplasms Prostate Cancer |
|
| rs191064896 |
Lymphoid Neoplasms Breast Cancer |
|
|
rs555607708 (CHEK2) rs146381257 (ZNF106) |
Prostate Cancer Breast Cancer Lung Cancer Bladder Cancer Lymphoid Neoplasms |
|
|
SLC6A2 ATM CHEK2 SAMHD1 BRCA2 |
Multiple primary cancer | |
| ATM | Prostate Cancer with other canc | |
|
BRCA1 BRCA2 |
Breast Cancer with other cancer | |
| 20501759 |
FAS-670 AG/GG FASLG-844 CT/TT |
Head and neck cancer with other cancer |
|
19955391 34078296 |
P21 p27 |
Head and neck cancer with other cancer |
| 24113849 | TNF-α−238 | Non-small cell lung cancer as SPC |