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. 2025 Jan 24;23:115. doi: 10.1186/s12967-025-06151-9

Table 3.

Examples of pathways that increase the risk of developingmultiple primary cancers

PMID Pathway Cancers
36313724 EGFR Co-occurrence of breast and lung cancers
34067022 PI3K/mTOR Co-occurrence of melanoma and renal cellcarcinoma
22577058 PI3K/PTEN/AKT/MTOR Second primary cancer after head and necksquamous cell carcinoma