. 2025 Jan 3;14:101890. doi: 10.1016/j.toxrep.2025.101890

Table 1.

Binding affinity, activation potency, and activation efficacy of 2C and NBOMe drugs on 5-HT receptors (adapted from [25]).

Drug / Receptor	5-HT_1A	5-HT_2A	5-HT_2B	5-HT_2C	Model
	Receptor Binding K_i (nM)
2C-B	240	8.6	-	47	HEK293 cells expressing human 5-HT_1A, 5-HT_2A and 5-HT_2C receptors
2C‐T‐7	520	6.5	-	39
25B-NBOMe	3600	0.5	-	6.2
25T7-NBOMe	1800	1.1	-	6.4
LSD	3	4.2	-	15
	Activation potency EC₅₀ (nM)
2C-B	-	80	130	-	NIH-3T3 and HEK293 cells expressing human 5-HT_2A and 5-HT_2B receptors, respectively
2C‐T‐7	-	130	350	-
25B-NBOMe	-	40	10	-
25T7-NBOMe	-	260	310	-
LSD	-	260	12,000	-
	Activation efficacy % maximum
2C-B	-	45	89	-
2C‐T‐7	-	76	45	-
25B-NBOMe	-	28	19	-
25T7-NBOMe	-	41	14	-
LSD	-	28	71	-