Table 6.

Summary of discriminative stimulus effects.

Training Drug	Drugs that totally substituted the training drug ≥ 80 % of drug appropriate responding	Model and route of administration	Ref
LSD (0.1 mg/kg)	2.5 mg/kg of 2C-E: 97 % 2.5 mg/kg of 2C-D: 83 % 5 mg/kg of 2C-I: 80 %	Sprague-Dawley rats IP	[29]
DMT (5 mg/kg)	2.5 mg/kg of 2C-D: 100 % 2.5 mg/kg of 2C-I: 93 % 5 mg/kg of 2C-E: 80 %
DOM (0.5 mg/kg)	2.5 mg/kg of 2C-D: 100 % 2.5 mg/kg of 2C-E: 97 % 2.5 mg/kg of 2C-C: 82 %
MDMA (1.5 mg/kg)	10 mg/kg of 2C-E: 100 % 2.5 mg/kg of 2C-C: 89 %
DOM (0.5 mg/kg)	0.5 mg/kg of 25B-NBOMe: 83 % 1 mg/kg of 25C-NBOMe: 97 %	Sprague-Dawley rats IP	[50]
MDMA (1.5 mg/kg)	0.5 mg/kg of 25B-NBOMe: 92 %
DOM (0.32 mg/kg)	0.32 mg/kg of 2C-T−7: > 90 %	Rhesus Monkeys SC	[52]
Training Drug	Drugs that partially substituted the training drug ≥ 40 % of drug appropriate responding	Model and route of administration	Ref
LSD (0.1 mg/kg)	5 mg/kg of 2C-C: 75 %	Sprague-Dawley rats IP	[29]
DMT (5 mg/kg)	5 mg/kg of 2C-C: 75 % 2.5 mg/kg of 2C-T−2: 73 %
MDMA (1.5 mg/kg)	2.5 mg/kg of 2C-D: 61 % 2.5 mg/kg of 2C-I: 65 %
DOM (0.5 mg/kg)	1 mg/kg of 25B-NBOMe: ∼ 50 % 2.5 mg/kg of 25I-NBOMe: 74 %	Sprague-Dawley rats IP	[50]
MDMA (1.5 mg/kg)	1 mg/kg of 25B-NBOMe: ∼ 50 % 1 mg/kg of 25C-NBOMe: 67 % 1 mg/kg of 25I-NBOMe: 78 %
LSD (0.1 mg/kg)	1 and 3 mg/kg of 2C-T−7: 75 %	Fischer-344 rats IP	[38]

LSD (lysergic acid diethylamide), DMT (N,N,-dimethyltryptamine); DOM (dimethyltryptamine); MDMA (3,4-methyl enedioxy methamphetamine); SC (Subcutaneous); IP (Intraperitoneal).