Table 8.
Summary of dopamine signaling pathways.
| Drug | Brain regions | DA levels |
DRD1 levels |
DRD2 levels |
DAT levels |
p-DAT levels |
TH levels |
Ref |
|---|---|---|---|---|---|---|---|---|
| 2C-C | NAc | - | NA | ↓ | ↓ | ↑ | - | [12] |
| mPFC | - | ↓ | NA | NA | ↑ | - | ||
| Striatum | - | - | - | - | - | NA | ||
| 2C-P | NAc | - | NA | ↓ | ↓ | ↑ | - | |
| mPFC | - | ↓ | NA | NA | NA | - | ||
| Striatum | - | - | - | - | - | NA | ||
| 25B-NBOMe | NAc | ↑ | ↑ | ↓ | - | - | - | [9] |
| VTA | - | - | ↓ | ↓ | - | - | ||
| 25D-NBOMe | NAc | ↑ | ↑ | ↓ | ↓ | ↑ | ↑ | [14] |
| 25E-NBOMe | NAc | ↓ | ↑ | NA | ↑ | - | - | [15] |
| 25H-NBOMe | Striatum | ↑ | - | - | - | - | - | [13] |
| 25I-NBOMe | Striatum | ↑ | - | - | - | - | - | [10] |
| Frontal cortex | ↑ | - | - | - | - | - | [42] | |
| 25N-NBOMe | NAc | - | NA | ↓ | ↓ | ↑ | ↓ | [11] |
| Striatum | - | NA | ↓ | NA | ↑ | NA |
NA (not altered); NAc (nucleus accumbens); mPFC (medial prefrontal cortex); VTA (ventral tegmental area); DA (dopamine); DRD1 (dopamine D1 receptor); DRD2 (dopamine D2 receptor)); DAT (dopamine transporter); p-DAT (phosphorylated-DAT); TH (tyrosine hydroxylase).