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. 2025 Jan 9;15(1):89. doi: 10.3390/biom15010089

Figure 2.

Figure 2

Identification of amylin residues that align structurally with amyloid β. (A) Summary of FATCAT structurally aligned residues of amylin and signaling domain (full structure). (Mean = 2.2; standard deviation = 1.8.) Hits are the number of occurrences in the FATCAT structural alignments per position. (Mean = 5.76; standard deviation = 2.7.) Hit values greater than the mean are in bold. Hit values greater than 1 standard deviation above the mean are highlighted in red. The RMSD for the alignments is shown at the bottom. Out of the 28 possible alignments, only those with an RMSD < 2 Å for human amylin compared to wild-type amyloid β were utilized for this analysis. (B) Dot plot alignment of human amylin (vertical) compared to wild-type amyloid β (horizontal) for the FATCAT alignments with RMSD < 2.0 Å. The number of times each residue matched between the two sequences is indicated in each box.