Table 3.

Structures and IC₅₀s of compound 9 and its derivatives on hCDC14A and B.^a

Compound	R Structure	IC50, μM		Compound	R Structure	IC50, μM
		hCDC14A	hCDC14B			hCDC14A	hCDC14B
9	-H	9.85 ± 0.30	12.78 ± 0.41	14		3.21 ± 0.25	5.85 ± 0.33
10	-Br	9.41 ± 0.41	11.88 ± 0.44	15		0.09 ± 0.01	0.22 ± 0.02
11		1.92 ± 0.16	2.17 ± 0.24	16		2.00 ± 0.42	4.19 ± 0.17
12		2.17 ± 0.24	5.21 ± 0.46	17		2.74 ± 0.27	3.77 ± 0.39
13		2.78 ± 0.44	3.76 ± 0.25

^aDetails of the enzyme assays are provided under Experimental Section. IC₅₀ values are mean ± standard deviation (SD) of the results from 3 independent experiments.