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. 2005 Jun 30;24(14):2512–2523. doi: 10.1038/sj.emboj.7600713

Figure 6.

Figure 6

mRNP targeting in S. pombe and S. cerevisiae. In S. pombe, the progression of mRNP formation starts following recruitment of Uap56p, Mlo3p and Dss1p. Direct interaction of Uap56p and Dss1p with Rae1p connects Mlo3p to the NPC (mRNA cargo not shown). Presumptive interactions between Dss1p inside the complex and –FG sequences of Nup98p are shown based on their direct interaction in vitro. At the nuclear pore, Rae1p associates with Nup98p (our unpublished results). Additional proteins may be involved in the process in vivo (not shown). For comparison, the major mRNA export pathway in S. cerevisiae via NXF–NXT homolog Mex67p–Mtr2p is shown. Unlike in S. cerevisiae, NXF–NXT pathway plays a minor role in S. pombe (see text for details).