Buffy, a Drob-1 antagonist, enhances polyglutamine-induced neurodegeneration. (A, B) Longevity curve of each genotype indicated is shown. (C–F) Adult eyes of 1-day-old flies with the following genotypes are shown: (C) GMR-GAL4/CySM1, (D) GMR-GAL4/CySM1; UAS-MJDtr-Q78/+, (E) GMR-GAL4/UAS-buffy; UAS-MJDtr-Q78/+, and (F) GMR-GAL4/UAS-buffy.