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. 2005 Jul 7;24(14):2700–2713. doi: 10.1038/sj.emboj.7600721

Figure 7.

Figure 7

Knockdown of Drob-1 specifically enhances rotenone- or 3-NP-induced cell death in S2 cells. (A–E) Cells were transfected with EGFP, drob-1, or buffy dsRNA for 48 h, and left untreated or treated with rotenone (0.05, 0.2, 1, 5, and 20 μM) (A), 3-NP (0.5, 2, 10, 50, and 100 mM) (B), antimycin A (0.02, 0.1, 0.5, 2, and 10 μg/ml) (C), KCN (0.01, 0.1, 1, and 10 μM) (D), or oligomycin (0.01, 0.1, 1, and 10 μM) (E). Mean±s.e.m., n=3, *P<0.05, **P<0.005, and ***P<0.0005 for cells with drob-1 dsRNA, †P<0.05, ††P<0.005, and †††P<0.0005 for cells with buffy dsRNA as compared with control cells (with EGFP dsRNA) by paired Student's t-test.