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. 2005 Jun 30;24(14):2543–2555. doi: 10.1038/sj.emboj.7600729

Figure 1.

Figure 1

Effect of TSA on Runx2-mediated transcription from OSE2 sequences. (A) TSA reverses TGF-β-induced repression of Runx2 activity at 6OSE2-luc in NIH3T3 cells. Cells were transfected with a Runx2 plasmid and the 6OSE2-luc reporter. After 24 h, cells were treated with TSA for 16 h in the presence or absence of TGF-β, and the luciferase activity was measured. (B, C) TSA does not affect activation of transcription by TGF-β at the 3TP or Smad7 promoters. (D) TSA inhibits TGF-β-induced repression of endogenous osteocalcin mRNA expression in the ROS17/2.8 cells, as assessed by real-time PCR.