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. 2005 Jun 30;24(14):2499–2511. doi: 10.1038/sj.emboj.7600736

Figure 7.

Figure 7

Regulation of SLC26A6 bicarbonate transport by metabolon disruption. CAII binds the CAB site (stippled) within the STAS domain of SLC26A6. Localization of CAII to the CAB site maximizes the local HCO3− concentration at the SLC26A6 transport site, thereby maximizing transport rate. PKC phosphorylates SLC26A6 at S553, which displaces CAII from the CAB site. Isolation of CAII from the surface of SLC26A6 reduces the local concentration of HCO3−, reducing the transport rate. Arrows on the SLC26A6 image represent the movement of Cl− and HCO3−, where the arrow width indicates the relative rate in each case.