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. 1971 Feb;121(3):549–555. doi: 10.1042/bj1210549

The computed distribution of copper(II) and zinc(II) ions among seventeen amino acids present in human blood plasma

P S Hallman 1,*, D D Perrin 1, Ann E Watt 1
PMCID: PMC1176604  PMID: 5119792

Abstract

The equilibrium distribution of copper(II) and zinc(II) ions among a mixture of 17 amino acids has been computed from stability-constant and blood-plasma-composition data. At pH7.4, 98% of the copper(II) in the simulated plasma solution is co-ordinated to histidine and cystine, predominantly as the mixed-ligand complexes [Cu·His·Cystine]− and [Cu·H·His·Cystine]. Approximately half of the zinc(II) is co-ordinated to cysteine and histidine, but appreciable complex-formation occurs with most of the other amino acids. Stability constants are given for copper(II) and zinc(II) amino acid complexes, including some mixed-ligand species, at 37°C and I=0.15m.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brigham M. P., Stein W. H., Moore S. THE CONCENTRATIONS OF CYSTEINE AND CYSTINE IN HUMAN BLOOD PLASMA. J Clin Invest. 1960 Nov;39(11):1633–1638. doi: 10.1172/JCI104186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CARTWRIGHT G. E., WINTROBE M. M. COPPER METABOLISM IN NORMAL SUBJECTS. Am J Clin Nutr. 1964 Apr;14:224–232. doi: 10.1093/ajcn/14.4.224. [DOI] [PubMed] [Google Scholar]
  3. McCormick D. B., Sigel H., Wright L. D. Structure of Mn2+ and Cu2+ complexes with L-methionine, S-methyl-L-cysteine, L-threonine and L-serine. Biochim Biophys Acta. 1969 Jul 30;184(2):318–328. doi: 10.1016/0304-4165(69)90034-8. [DOI] [PubMed] [Google Scholar]
  4. Neumann P. Z., Sass-Kortsak A. The state of copper in human serum: evidence for an amino acid-bound fraction. J Clin Invest. 1967 Apr;46(4):646–658. doi: 10.1172/JCI105566. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Perrin D. D. Multiple equilibria in assemblages of metal ions and complexing species: a model for biological systems. Nature. 1965 Apr 10;206(980):170–171. doi: 10.1038/206170a0. [DOI] [PubMed] [Google Scholar]
  6. Perrin D. D., Sayce I. G. A pH-titration cell for precise measurements. Chem Ind. 1966 Apr 16;16:661–661. [PubMed] [Google Scholar]
  7. STEIN W. H., MOORE S. The free amino acids of human blood plasma. J Biol Chem. 1954 Dec;211(2):915–926. [PubMed] [Google Scholar]
  8. Sarkar B., Wigfield Y. Evidence for albumin--cu(II)--amino acid ternary complex. Can J Biochem. 1968 Jun;46(6):601–607. doi: 10.1139/o68-092. [DOI] [PubMed] [Google Scholar]

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