Table 2.

The evidence of various dendrimers used for cancer treatment.

Dendrimers	Conjugated Molecules	Drug	Type of Cancer	Conditions	Ref.
Plain dendrimers
Poly (propylene imine) dendrimer (PPI)	Chemical conjugation	Melphalan	Breast	In vitro	[47,48]
Polyether dendrimers	D-glucose amine	Methotrexate (MTX)	Gliomas (malignant cancer)	In vitro	[49]
Poly-l-lysine dendrimers (PLL)	-	DOX	Lung and ovarian	In vitro and in vivo	[50]
Melamine dendrimer	Organoiron	Piperazine moieties	Breast	In vitro	[51]
Triazine dendrimer	-	Paclitaxel	Prostate	In vivo and in vitro	[52]
Poly (amidoamine) PAMAM dendrimer	Enzyme linked aptamer	Au-nanoparticles and prostate-specific antigen (PSA)	Prostate	In vitro	[53]
Polyester dendrimer	Manganese	Hypericin	Breast	In vitro	[54]
Citric acid dendrimer	Polyethylene glycol (PEG)	Alendronate	Bone	In vitro	[55]
Dendrimers based on macromolecular monomers
Peptide dendrimer	Tetra-peptide sequence Gly-Phe-Leu-Gly (GFLG)	DOX	Ovarian	In vivo and in vitro	[53]
Carbohydrate dendrimer	D glucosamine	Methotrexate	Glioma	In vitro	[56]
PEG dendrimers	Di sulfide linkage	PTX and TR3 siRN	Pancreatic	In vitro and in vivo	[57]
Surface engineered dendrimers
Acetylated dendrimer	Fluorescein isothiocyanate (FITC)	Biotin	Breast	In vitro	[58]
Antibody conjugated dendrimer	J591 anti-PSMA (prostate-specific membrane antigen), fluorophores	-	Prostate	In vitro	[59]
Folate conjugated dendrimer	PAMAM	MTX	Cervical and ovarian	In vitro	[60]
SiRNA conjugated dendrimer	PAMAM	-	Breast	In vivo	[61]
Dendrimers with special property
Amphiphilic dendrimer	Peptide	DOX	Breast	In vivo and in vitro	[62]
Liquid crystalline dendrimer	Lyotropic	DOX	Ovarian	In vivo and in vitro	[63]
Hybrid dendrimer	Lipid	Paclitaxel	Ovarian	In vivo and in vitro	[64]
Micellar dendrimer	Micelles	Paclitaxel	Breast	In vivo	[65]
Multilingual dendrimer	Functional group	Methotrexate (MTX)	Cervical	In vivo	[66]