TABLE 2.

Recovery of know impurities in selpercatinib.

Substance	Target level	Spiked conc. (μg/mL)	Determined conc. (μg/mL)	Recovery (%)	Average recovery rate (%)	RSD (%)
imp-A	50%	0.511	0.508	99.41	99.53	2.42
		0.511	0.528	103.33
		0.511	0.499	97.65
	100%	1.021	1.052	103.04
		1.021	0.992	97.16
		1.021	1.032	101.08
	150%	1.532	1.516	98.96
		1.532	1.492	97.39
		1.532	1.498	97.78
imp-B	50%	0.508	0.495	97.44	99.29	2.15
		0.508	0.512	100.79
		0.508	0.499	98.23
	100%	1.016	0.998	98.23
		1.016	1.029	101.28
		1.016	0.986	97.05
	150%	1.524	1.506	98.82
		1.524	1.497	98.23
		1.524	1.578	103.54
imp-C	50%	0.506	0.495	97.83	97.40	1.84
		0.506	0.487	96.25
		0.506	0.511	100.99
	100%	1.012	0.995	98.32
		1.012	0.975	96.34
		1.012	0.968	95.65
	150%	1.518	1.455	95.85
		1.518	1.462	96.31
		1.518	1.504	99.08
imp-D	50%	0.517	0.523	101.16	98.11	2.09
		0.517	0.508	98.26
		0.517	0.493	95.36
	100%	1.034	1.008	97.49
		1.034	0.992	95.94
		1.034	1.026	99.23
	150%	1.551	1.493	96.26
		1.551	1.529	98.58
		1.551	1.562	100.71