Table 1.
Pharmacokinetic parameters for N,N-DMT and its metabolites, and harmine and its metabolite in the DMT + harmine condition and harmine + placebo condition based on non-compartmental analyses.
| Condition marker |
Cmax (ng/mL) | tmax (h) | t1/2 (h) | AUCall (ng × h/mL) | AUCinf (ng × h/mL) |
|---|---|---|---|---|---|
| DMT + harmine | |||||
| DMT | 22.1 (7.1) | 2.7 (0.5) | 0.6 (0.3) | 56.6 (17.3) | 59.9 (19.4) |
| DMT-N-oxide | 21.0 (7.0) | 3.2 (0.6) | 1.2 (0.4) | 55.4 (17.8) | 69.2 (22.1) |
| NMT | 0.4 (0.3) | 3.3 (0.7) | 2.4 (2.4) | 1.0 (0.6) | 1.6 (1.6) |
| 3-IAA | 2912.2 (1442.8) | 4.1 (0.6) | - | 7578.7 (3250.2) | - |
| Harmine | 32.5 (12.2) | 1.6 (0.6) | 1.4 (0.7) | 89.1 (36.1) | 104.1 (48.0) |
| Harmole | 12.0 (8.3) | 1.6 (1.2) | 1.8 (1.4) | 29.5 (17.6) | 36.8 (20.6) |
| Harmine + placebo | |||||
| Harmine | 33.5 (17.6) | 1.4 (0.4) | 1.5 (0.8) | 83.5 (47.7) | 99.5 (63.8) |
| Harmole | 12.5 (7.5) | 1.6 (0.6) | 2.0 (0.8) | 26.4 (13.2) | 32.6 (15.6) |
Means and SDs (displayed in brackets) are shown. Temporal values refer to the administration time of DMT or harmine.
Abbreviations: AUCall, area under the plasma concentration-time curve from time zero to last time point; AUCinf, area under the plasma concentration-time curve from time zero to infinity; Cmax, estimated maximum plasma concentration; DMT, N,N-dimethyltryptamine; 3-IAA, indole-3-acetic acid; NMT, N-methyltryptamine; t1/2‐, estimated plasma elimination half-life; tmax, estimated time to reach Cmax.