Table 2.
Univariable and multivariable Cox regression analyses of the variables for overall survival (OS) in 108 patients with hepatocellular carcinoma.
| Variables | Univariable predictors of OS |
Multivariable predictors of OS |
||||
|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |||
| Age | ≤50 years | 1 | ||||
| >50 years | 0.888 (0.546–1.444) | 0.632 | ||||
| Sex | Male | 1 | ||||
| Female | 0.708 (0.284–1.765) | 0.458 | ||||
| HBsAg presence | No | 1 | ||||
| Yes | 1.643 (0.597–4.525) | 0.336 | ||||
| Liver cirrhosis | No | 1 | ||||
| Yes | 2.675 (0.371–19.294) | 0.329 | ||||
| Presurgical TACE | No | 1 | ||||
| Yes | 0.992 (0.606–1.625) | 0.974 | ||||
| Child–Pugh score | A or B | 1 | ||||
| C | 2.555 (1.491–4.378) | 0.001 | 1.732 (0.987–3.040) | 0.056 | ||
| Serum AFP | ≤400 ng/mL | 1 | ||||
| >400 ng/mL | 2.422 (1.478–3.969) | <0.001 | 1.857 (1.118–3.082) | 0.017 | ||
| Tumor number | ≤3 | 1 | ||||
| >3 | 2.589 (1.581–4.238) | <0.001 | 1.681 (0.998–2.831) | 0.051 | ||
| Tumor size | ≤5 cm | 1 | ||||
| >5 cm | 1.483 (0.909–2.420) | 0.114 | ||||
| Tumor differentiation | Well or moderate | 1 | ||||
| Poor | 1.930 (1.145–3.253) | 0.014 | 1.266 (0.709–2.263) | 0.425 | ||
| Microvascular invasion | No | 1 | ||||
| Yes | 2.822 (1.715–4.644) | <0.001 | 1.931 (1.127–3.309) | 0.017 | ||
| GDF7 expression | Low | 1 | ||||
| High | 0.342 (0.186–0.631) | 0.001 | 0.471 (0.251–0.885) | 0.019 | ||
Abbreviations: AFP, alpha-fetoprotein; CI, confidence interval; GDF7, growth differentiation factor 7; HBsAg, hepatitis B surface antigen; HR, hazard ratio; TACE, transarterial chemoembolization.