Table 3.
Univariable and multivariable Cox regression analyses of the variables for recurrence-free survival (RFS) in 108 patients with hepatocellular carcinoma.
| Variables | Univariable predictors of RFS |
Multivariable predictors of RFS |
||||
|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |||
| Age | ≤50 years | 1 | ||||
| >50 years | 0.677 (0.425–1.078) | 1.000 | ||||
| Sex | Male | 1 | ||||
| Female | 0.517 (0.223–1.195) | 0.123 | ||||
| HBsAg presence | No | 1 | ||||
| Yes | 2.065 (0.752–5.666) | 0.159 | ||||
| Liver cirrhosis | No | 1 | ||||
| Yes | 0.346 (0.107–1.121) | 0.077 | 0.436 (0.130–1.462) | 0.179 | ||
| Presurgical TACE | No | 1 | ||||
| Yes | 0.988 (0.618–1.578) | 0.959 | ||||
| Child–Pugh score | A or B | 1 | ||||
| C | 2.209 (1.300–3.755) | 0.003 | 1.440 (0.816–2.540) | 0.208 | ||
| Serum AFP | ≤400 ng/mL | |||||
| >400 ng/mL | 2.600 (1.621–4.170) | <0.001 | 1.990 (1.224–3.236) | 0.006 | ||
| Tumor number | ≤3 | 1 | ||||
| >3 | 2.744 (1.710–4.404) | <0.001 | 1.659 (0.998–2.758) | 0.051 | ||
| Tumor size | ≤5 cm | 1 | ||||
| >5 cm | 1.732 (1.083–2.771) | 0.022 | 1.329 (0.800–2.207) | 0.272 | ||
| Tumor differentiation | Well or moderate | 1 | ||||
| Poor | 1.765 (1.084–2.874) | 0.022 | 1.224 (0.676–2.215) | 0.505 | ||
| Microvascular invasion | No | 1 | ||||
| Yes | 3.132 (1.943–5.050) | <0.001 | 2.307 (1.366–3.898) | 0.002 | ||
| GDF7 expression | Low | 1 | ||||
| High | 0.343 (0.193–0.608) | <0.001 | 0.425 (0.236–0.766) | 0.004 | ||
Abbreviations: AFP, alpha-fetoprotein; CI, confidence interval; GDF7, growth differentiation factor 7; HBsAg, hepatitis B surface antigen; HR, hazard ratio; TACE, transarterial chemoembolization.